WANG, YUQIANG,LIU, ZHENG,YU, PEI,SUN, YEWEI,ZHANG, ZAIJUN,ZHANG, GAOXIAO,SHAN, LUCHEN,YI, PENG,LARRICK, JAMES
申请号：
CA2950452
公开号：
CA2950452A1
申请日:
2015.05.08
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention relates to an amantadine nitrate compound having a neuroprotective effect and a preparation and a medical use thereof. The compound has the structure of the general formula (I). The compound has multiple mechanisms of action, comprising inhibiting DNA receptors, releasing NO, inhibiting calcium influxes, and having a better protective effects on cells, in particular neurocytes. The compound can be used for preparing a medicament having a cellular protective effect, which is used for preventing or treating diseases relevant to NMDA receptors, the elevation of the calcium anion in cells and the like, e.g. diseases relevant to neurodegeneration, comprising Alzheimer's disease, Parkinson's disease, cerebral paralysis, glaucoma and the like, and diseases relevant to the cardio-cerebral-vascular system, such as Parkinson's syndrome combined with cerebral arteriosclerosis, as well as preventing or treating respiratory tract infectivity caused by the influenza virus.
