The present invention generally relates to the field of bone substitute materials and particularly to a bone substitute material that is bioactivated. More specifically the present invention relates to a particular agent comprising citrate citric acid monobasic sodium phosphate dextrose and adenine for use in improving or promoting osseointegration of a bone substitute material to a bone substitute material provided with a coating of said particular agent and to a kit for use in a method of installing a bone substitute material comprising a bone substitute material as well as citrate citric acid monobasic sodium phosphate dextrose and adenine.
