A device 100 for puncturing a capsule 219 to release a powdered medicament therefrom comprises a chamber 210 for receiving a capsule 219 comprising opposing domes 404, 408 and a cylindrical wall portion 412 defined by a capsule wall radius r. The device further comprises a mechanism 230 for puncturing at least one hole 504, 508 in at least one dome, a center of each hole located within an annular puncture region 428 situated at no less than 0.4r. A total surface area of all puncture holes is between about 0.5% and about 2.2% of a total surface area of the capsule.
