Pharmaceutical Combination comprising an inhibitor Compound of phosphatidyl inositol 3 Kinase (PI3K), which is a Derivative of 2 - carboxamide - cicloamino - ureaOr a pharmaceutically acceptable Salt thereof, and at least an inhibitor of the mammalian target of rapamycin (mTOR), or a pharmaceutically acceptable Salt thereof.Pharmaceutical composition, comprising Said Combination； and Uses of this combination in the treatment of proliferative diseases.More specifically, the dependent Diseases the kinase mammalian target of rapamycin (mTOR).Claim 1: a Pharmaceutical combination, which comprises: a) a compound of the formula (1) or a Salt thereof,Where: is a heteroaryl Group selected from Formulae (2)； r1 represents one of the following: (i) alkyl substituents C1 - 7 insustituido or replaced,Preferably replaced, where the substituents are selected independently from one or more, preferably one to nine of the following fractions: deuterium fluorideOne or two of the following fractions: cycloalkyl C3 - 5； (ii) optionally substituted cycloalkyl c3-5, where the substituents are selected independently from one or more,Preferably one to four of the following fractions: deuterium, c1-4 alkyl (METHYL FLUORIDE, preferably), cyano, amino carbonyl； (iii) phenyl optionally substituted,Where the substituents are selected independently from one or more, preferably one to two of the following fractions: deuterium Halogen, alkyl, cyano, C1 - 7C1 - 7 - amino alkyl, di - (alkyl C1 - 7 - amino alkyl), C1 - 7 - amino carbonyl, di - (alkyl C1 - 7 - amino carbonyl)C1 - 7 alkoxyl Amine； (iv) optionally substituted mono - or di -, where the substituents are selected independently from the following Parts: deuteriumAlkyl C1 - 7 (which is insustituido or replaced by one or more substituents selected from the group of deuterium, Fluorine, Chlorine, hydroxyl)PHENYL sulfonyl insustituido (or is replaced by one or more, preferably One alkoxyl alkyl of C1 - C1 - 7 7Di - (C1 - 7 - amino alkyl alkoxyl
