ARTMAN III, Gerald David,ELLIOTT, Jason Matthew,JI, Nan,LIU, Donglei,MA, Fupeng,MAINOLFI, Nello,MEREDITH, Erik,MIRANDA, Karl,POWERS, James J.,RAO, Chang
申请号：
ES09774876
公开号：
ES2633959T3
申请日:
2009.12.07
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of the formula III: ** (See formula) ** or a salt thereof, wherein: R1 is hydrogen or C1-C6alkyl； R3 is hydrogen or C1-C6alkyl； R5 is hydrogen or halogen； R7 is hydrogen or C1-C6alkyl； X is O or S； R8 is selected from the group consisting of hydrogen and C1-C4alkyl； R9 is selected from the group consisting of (CH2) nNHR13, (CR11R12) n-heterocycle, (CR11R12) nOR15, (CH2) nS (O) mR17 and (CH2) nS (O) mN (R18) 2； Ar2 is a five-membered heteroaryl ujn having 1 ring nitrogen atom and 0 or 1 additional ring heteroatoms selected from N and O and wherein said heteroaryl group is unsubstituted or substituted with 1 or 2 groups independently selected from the group that It consists of C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy, halogen, amino, aminoC1-C4alkyl, mono- and di-C1-C4alkylaminoC1-C4alkyl, mono- and di-C1-C4alkylamino, hydroxyl, CO2C1- C4alkyl, phenylC0-C4alkyl, C3-C6ylcoalkylC0-C2alkyl, aminosulfonyl, and mono- and di-C1-C4alkylaminosulfonyl； m is 0, 1, or 2； n is 1 or 2； R11 and R12 are the same or different and are independently selected in each case from the group consisting of hydrogen and C1-C4alkyl； R13 is hydrogen, C1-C4alkyl, hydroxyC1-C4alkyl, or C3-C6cycloalkyl； R15 is hydrogen or C1-C4alkyl； R17 is C1-C4alkyl； and R18 is independently selected in each case from the group consisting of hydrogen, methyl or ethyl.Un compuesto de la fórmula III: **(Ver fórmula)** o una sal del mismo, en donde : R1 es hidrógeno o C1-C6alquilo； R3 es hidrógeno o C1-C6alquilo； R5 es hidrógeno o halógeno； R7 es hidrógeno o C1-C6alquilo； X es O o S； R8 se selecciona del grupo que consiste de hidrógeno y C1-C4alquilo； R9 se selecciona del grupo que consiste de (CH2)nNHR13, (CR11R12)nheterociclo, (CR11R12)nOR15, (CH2)nS(O)mR17 y (CH2)nS(O)mN(R18)2； Ar2 es ujn heteroarilo de cinco miembros que tiene 1 átomo de nitrógeno en el anillo y 0 o 1 heteroátomos de anillo adicionales seleccionados de N y O y en donde dicho grupo heteroarilo está sin sustituir o susti
