The invention relates in various aspects to stem cells comprising a synthetic chimeric poxvirus (scPV), which can be used for the treatment of cancer or other infectious diseases. It also relates to methods for delivering the scPV comprising infecting the stem cells with the scPV and administering the infected stem cells to a subject.本發明在各種態樣中係關於包含合成嵌合痘病毒(scPV)之幹細胞,其可用於治療癌症或其他傳染病。本發明亦關於用於遞送該scPV之方法,其包含用該scPV感染該等幹細胞且向個體投與該等經感染幹細胞。