A valve prosthesis (10), comprising a stent (1), a leaflet (2), and a skirt (3)； the stent (1) comprises an inflow end, an outflow end, and a plurality of wavy segments axially connected； the wavy segments comprise a plurality of reticular structure units disposed circumferentially； the leaflet (2) and the skirt (3) are fixed on the stent (1) respectively； the upper portion of the skirt (3) is provided with indentations (321)； the skirt (3) is fixed with the leaflet (2) by means of the indentations (321)； the skirt (3) further comprises first protrusion portions (323) extending toward the direction of the outflow end of the stent； one ends of the first protrusion portions (323) are connected with the indentations(321), and the other ends of the first protrusion portions are fixed to the stent (1)； by such a way, the connection strength of the skirt (3) and the stent (1) is enhanced； and besides, when the valve prosthesis (10) is implanted at a lower position, perivalvular leakage preventing height can be increased by means of the first protrusion portions (323), thereby avoiding the leakage of a part of blood from the stent (1) and further improving the perivalvular leakage preventing effect.
