The disclosure relates to Cyclic Urea- or Lactam-Substituted Quinoxaline-Type Piperidine Compounds of Formula (I): and pharmaceutically acceptable derivatives thereof wherein R1, R2, Qa, Y1, Z, A, B, Qx, E, G, J, M, U, W, and a are as defined herein, compositions comprising an effective amount of a Cyclic Urea- or Lactam-Substituted Quinoxaline-Type Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Cyclic Urea- or Lactm-Substituted Quinoxaline-Type Piperidine Compound.本發明係關於式(I)所示之經環狀脲或內醯胺取代之喹啉型哌啶化合物：和其藥學上可接受之衍生物(其中R1、R2、Qa、Y1、Z、A、B、Qx、E、G、J、M、U、W與a如本案中所定義)、含有有效量的經環狀脲或內醯胺取代之喹啉型哌啶化合物的組成物以及治療或預防病症(像疼痛)之方法，其包含將有效量的經環狀脲或內醯胺取代之喹啉型哌啶化合物投予需要的動物。
