MITCHELL S. STEINER,米契尔 S. 史坦纳,米契爾 S. 史坦納,KAREN A. VEVERKA,凯伦 A. 维佛卡,凱倫 A. 維佛卡,DUANE D. MILLER,彤恩 D. 米勒,JAMES T. DALTON,詹姆士 T 戴尔顿,詹姆士 T 戴爾頓,WENQING GAO,温昆 高,溫昆 高,KIWON CHUNG,齐温 张,齊溫 張
申请号：
TW092102512
公开号：
TWI374737B
申请日:
2003.02.07
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
This invention provides a method of treating, preventing, suppressing, inhibiting or reducing the incidence of benign prostate hyperplasia in a male subject, by administering to the subject a selective androgen receptor modulator (SARM) and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof as described herein. This invention also provides a method of treating a subject suffering from hair loss, comprising the step of administering to the subject a therapeutically effective amount of a 5-α reductase enzyme type 1 and/or type 2 inhibitor, wherein said inhibitor is a selective androgen receptor modulator (SARM) and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination there of as described herein. This invention also provides a method of inhibiting a 5-α reductase type 1 and/or type 2 enzyme, comprising contacting the enzyme with an effective 5-α reductase inhibitory amount of a selective androgen receptor modulator (SARM) and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof, as described herein. 本發明係提供一種藉由標的物投予選擇性雄激素受體調節劑(SARM)及/或其類似物、衍生物、異構體、代謝物、醫藥接受性鹽、醫藥產物、水合物、N-氧化物或如本文中所述之其任一種結合，治療、預防、壓制、抑制或降低男性患者良性前列腺肥大發生率之方法。本發明亦提供一種治療掉頭髮患者之方法，包括之步驟為對患者投予治療有效量之5-α還原酶酵素1型及/或2型抑制劑，其中該抑制劑為選擇性雄激素受體調節劑(SARM)及/或其類似物、衍生物、異構體、代謝物、醫藥接受性鹽、醫藥產物、水合物、N-氧化物或如本文中所述之其任一種結合。本發明亦提供一種抑制5-α還原酶1型及/或2型酵素之方法，包括使酵素與有效之5-α還原酶抑制量之選擇性雄激素受體調節劑(SARM)及/或其類似物、衍生物、異構體、代謝物、醫藥接受性鹽、醫藥產物、水合物、N-氧化物或如本文中所述之其任一種結合接觸。
