David Verhoeven,Jessie Dorothy Trujillo,Brett Sponseller
申请号：
US16400817
公开号：
US20190321459A1
申请日:
2019.05.01
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides vaccine or immunogenic compositions comprising novel antigens derived from the equine strain of influenza H3N8. These proteins and specific immunogenic domains are effective as primary universal influenza antigens. The disclosed vaccines or immunogenic compositions are highly effective in inducing HA specific antibodies reactive to different influenza viruses, mucosal and systemic immune responses, and cross-protection regardless of influenza virus subtypes. In some embodiments, the vaccine is cross-protective against two or more (e.g., 2, 3, 4, 5, or 6) subtypes of influenza with or without the use of an adjuvant.
