Benjamin L. MILLER;Elizabeth A. ANDERSON;Anna DE BENEDETTO;Lisa A. BECK
发明人:
Benjamin L. MILLER,Anna DE BENEDETTO,Lisa A. BECK,Elizabeth A. ANDERSON
申请号：
US14912098
公开号：
US20160199440A1
申请日:
2014.08.18
申请国别(地区):
US
年份:
2016
代理人:
摘要：
According to aspects illustrated herein, there is provided an agent that transiently disrupts claudin-1 within tight junctions. The agent includes a peptide having at least 40% polar, uncharged amino acid residues and a self-assembled β-sheet secondary structure. According to aspects illustrated herein, there is also provided a transepithelial drug and vaccine formulations, as well as isolated peptides, pharmaceutical compositions, and transdermal delivery devices. Also described herein are methods of disrupting epithelial barrier and methods of administering the transepithelial formulations described herein.
