Salomon Stavchansky;Ashish Rastogi;Zhiquan Luo;Zhuojie Wu;Phillip Bowman;Paul S. Ho
发明人:
Paul S. Ho,Salomon Stavchansky,Phillip Bowman,Zhiquan Luo,Zhuojie Wu,Ashish Rastogi
申请号:
US13383820
公开号:
US20120177716A1
申请日:
2010.07.14
申请国别(地区):
US
年份:
2012
代理人:
摘要:
A method of making an injectable or implantable active agent delivery device capable of delivering a diagnostic, therapeutic, and/or prophylactic agent to a desired targeted site having orifice(s) on the surface is disclosed herein providing unidirectional release of the agent at a controlled desirable rate. The agent may include, but is not limited to, drugs, proteins, peptides, biomarkers, bioanalytes, and/or genetic material. The technology of the invention is based on parallel processing to fabricate micro-holes on tubes employing photo-lithography and reactive ion etching techniques and also incorporates a simple molding method to form the micro-holes on flexible polymer tubes, including bio-degradable tubes. The parallel processing method of the instant invention is fast, economical and well suited for mass production. The developed device, due to its composite structure, has the ability to combine several release mechanisms, leading to zero-order release kinetics for most of the time.