Methods and systems for 4D electromagnetic tomographic differential (dynamic) fused imaging and mapping of electrical excitation of biological tissues. A plurality of electromagnetic field sources (26) and detectors (28) generate and detect an electromagnetic field domain in a target area. A biological tissue (19) is positioned within the target area, and an electromagnetic field domain is generated via a selected plurality of sources. The field generated by each source is selectively characterized so that each of a selected plurality of detectors recognizes a source of field from the plurality of sources. The sources and detectors are controlled so that fields generated by the selected sources are received by the selected detectors after interacting with the tissue. Based on the field received at each detector, a complex interference (scattering) matrix is derived from the tissue-generated field, and anatomical and functional image information are reconstructed from this matrix. The anatomical information and functional information are fused for display.
