HINTON, PAUL R.,TSURUSHITA, NAOYA,TSO, J. YUN,VASQUEZ, MAXIMILIANO
申请号：
CA2522331
公开号：
CA2522331C
申请日:
2004.04.09
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention provides for a modified antibody of class IgG, in whichat least one amino acid from the heavy chain constant region selected from thegroup consisting of amino acid residues 250, 314, and 428 is substituted withanother amino acid which is different from that present in the unmodifiedantibody, thereby altering the binding affinity for FcRn and/or the serum half-life in comparison to the unmodified antibody.
