The invention relates to a method and system for processing a test signal in medical domain comprising following steps:&mdashacquiring (110, 120, 130) an input digital signal F(t) function of time t in the form of two-dimensional data (t, F(t)), said signal F(t) resulting from the excitation, within a test substrate, of a substance adapted to emit a signal in response to said excitation&mdashmodeling (140) said input digital signal F(t) in function of a pre-established model&mdashpossibly, generating an output digital signal I(t) made up from said modeling wherein said modeling is based on the following model: (formula I) where the coefficients a0, a1, a2, p, q, A et B are estimated on the basis of said two-dimensional data. The invention is directed to the tumoral vascularization or tumoral angiogenesis detection in tumors.
