The present invention encompasses an oral composition containing an anti-adhesion agent, preferably a cysteine protease and most preferably ficin. In another aspect, the cysteine protease is in combination with one or more ingredients, such as antibacterial agent and surfactant. The anti-adhesion agent mitigates interaction between a subject oral cavity and plaque-forming materials.本發明包含一種口腔組成物,其含有一種抗-附著劑,較佳為胱胺酸蛋白酶且最佳為無花果蛋白酶。於另一方面,胱胺酸蛋白酶組合有一或多種成分,諸如抗菌劑和表面活性劑。抗-附著劑減輕對象之口腔和牙菌斑形成物質之間的交互作用。