UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES;IDENIX PHARMACEUTICALS, INC.;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人:
BENJAMIN ALEXANDER MAYES,ADEL M. MOUSSA,ALISTAIR JAMES STEWART
申请号：
ARP130101781
公开号：
AR092835A1
申请日:
2013.05.22
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Compounds, ingredients and methods for the treatment of diseases and liver conditions, including HCB infection. Some forms of implementation describe compounds and components of nucleoside derivatives that can be managed alone or in combination with other antiviral agents. Claim 1: a compound calculated according to formula (1),Or its salt, solvato, stereoisomerization, ceramic shape or drug approved polymorphic form, wherein: base is a core； a is s or O； W is s or O； X is a residue D-amino acid or its ester； and hydrogen, or1,-SR1,O-NrR7495； 1 is asphalt, cyclopentadiene -, h, azido, cyanogen, or halogen； r7495； es-oh -, Cl -, F -, h, azido, cyanogen, ammonia, or alcoxilo； or in other ways, r7495；； 1 and r749552；,They are combined with carbon atoms to form a carbon ring or heterocyclic ring composed of three members； r758080 es-h-oh, or in other ways, is combined with r758080 to form a heterocyclic ring composed of six members. In this ring, r758080 is combined to form a single heterocyclic ring.R7496es-h, - F, azido, or alenio； or another way, r74955； - and r74966 are combined to form tar or substitute tar； r7497es-h or tar； each R1 is an independent tar, cyclopropyl compound, arilo, isopropene, arilalquilo, isopropyl compound, tar or hidantonilalquilo； each R2 is an independent hydrogen or tar.Compuestos, composiciones y métodos para el tratamiento de enfermedades y condiciones del hígado, incluso infecciones HCV. En ciertas formas de realización se describen, compuestos y composiciones de derivados de nucleósidos que se pueden administrar ya sea solos o en combinación con otros agentes anti-virales. Reivindicación 1: Un compuesto de acuerdo con la fórmula (1), o su sal, solvato, forma estereoisomérica, forma tautomérica o forma polimórfica farmacéuticamente aceptadas, en donde: Base es una núcleobase； A es S u O； W es S u O； X es un residuo D-aminoácido, o su éster； Y es hidrógeno, -OR¹, -SR¹, ó -NR¹R²； Rᵇ¹ es alquilo, cicloalquilo, -H, azido, ciano, o halóg
