Composition for delaying senescence lifespan extension or preventing treating or improving of diseases caused by lipofuscin accumulation comprising sauchinone as an active ingredient of Saururus chinensis
The present invention relates to a composition for delaying senescence, extending a lifespan, or preventing, treating or alleviating a disease caused by lipofuscin accumulation comprising sauchinone of Saururus chinensis as an active ingredient and, more specifically, to a pharmaceutical composition, a functional food composition, a function feed composition, and a culture medium composition for a use for delaying senescence or extending a lifespan or a use for preventing, treating or alleviating a disease caused by lipofuscin accumulation comprising sauchinone which is one of the ingredients of Saururus chinensis or a salt thereof as an active ingredient. According to the present invention, the composition increases resistance against dry stress, thermal shock stress, and oxidation stress, increases the activity of superoxide dismutase (SOD) and catalase which are antioxidant enzymes, inhibits accumulation of reactive oxygen species (ROS), promotes creation of a protein resisting oxidation stress, and inhibits accumulation of lipofuscin to ultimately delay senescence or extend the lifespan of an animal. Specifically, the composition is effective only in growth of a weak body, and does not affect other physiological functions such as a reproductive ability, an intake amount of food, and a quantity of motion to eliminate physiological side effects. Also, the composition can inhibit the creation of lipofuscin in the body to effectively prevent, treat, or alleviate a disease caused by lipofuscin accumulation.본 발명은 삼백초 성분인 사우치논을 유효성분으로 함유하는 노화지연, 수명연장, 또는 리포푸신 축적으로 인한 질환의 예방, 치료 또는 개선용 조성물에 관한 것으로, 구체적으로 삼백초의 성분 중 하나인 사우치논 또는 이의 염을 유효성분으로 함유하는 노화를 지연하거나 수명을 연장하기 위한 용도 또는 리포푸신 축적으로 인한 질환을 예방, 치료 또는 개선하기 위한 용도의 약학 조성물, 기능성 식품 조성물, 기능성 사료 조성물 및 배지 조성물에 관한 것이다.본 발명의 조성물은 건조 스트레스, 열충격 스트레스 및 산화 스트레스에 대한 저항력을 증가시키고, 항산화 효소인 수퍼옥시드디스뮤타아제(superoxide dismutase, SOD) 및 카탈라아제(catalase)의 활성을 증가시키며, 활성산소종(reactive oxygen species, ROS)의 축적을 억제하고, 산화적 스트레스에 저항하는 단백질의 생성을 촉진하며, 리포푸신(l
