Herman Jan Tijmen Coelingh Bennink,Evert Johannes Bunschoten
申请号：
US10521040
公开号：
US09034854B2
申请日:
2003.07.11
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a method of treating or preventing estrogen-sensitive tumors in a mammal, said method comprising the administration of a therapeutically effective amount of an estrogenic component to said mammal, wherein the estrogenic component is selected from the group consisting of:substances represented by the following formulain which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms precursors capable of liberating a substance according to the aforementioned formula when used in the present method and mixtures of one or more of the aforementioned substances and/or precursors.The estrogenic component according to the invention does not have undesirable proliferative effects on breast and/or endometrial tissue and displays sufficient estrogenicity to prevent that its administration will lead to hypoestrogenism and/or climacteric complaints.
