Robert I. Tepper,Russell Hirsch,Jason E. Fuller,Jessica L. Duda,Craig Muir,Jeffrey S. Ross,J. Christopher Flaherty
申请号：
US13060040
公开号：
US10080876B2
申请日:
2009.08.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Described here are devices, systems, and kits for delivering substances to tissues. The devices generally include one or more chambers (102) and a reservoir (108) within each chamber. The reservoir may locally deliver a microdose amount of a substance to a target tissue. In some variations, a microdose amount is used in early human studies, e.g., before a phase I clinical trial, to evaluate the effect of the substance on a target tissue, or to obtain pharmacokinetic or metabolic data. In other variations, a microdose amount is used to locally treat a medical condition. In yet other variations, a microdose amount is used to locally deliver a contrast agent for a structural or functional imaging procedure. Methods for delivering and retrieving the devices from the target tissue are also described.
