The present invention provides suffer from hypercholesterolemia for treating, whereinThe patient is not responding to, so as to suitably control by or it is intolerant to standard liposomal modify treat. Method of the invention, which provides, to be reduced at least one lipid parameter patient, by giving the antibody of the specific bond of therapeutically effective amount or the antibody angiogenin sample egg 3 (ANGPTL3) of its antigen-binding fragment albumen conversion subtilisin/kexin types 9 (PCSK9) and the specific binding of therapeutically effective amount. It can be used for treating disease such as hypercholesterolemia including familial hypercholesterolemia (FH) in conjunction with anti-PCSK9 antibody and anti-ANGPTL3 antibody, two heFH and hoFH, and hyperlipidemia, hyperlipoprotememia and dyslipidemia, including hypertriglyceridemia, chylomicronemia, it is a kind of risk factor, such as cardiovascular disease for Dyslipidemia with prevention or treatment disease or illness.
