Jae Myoung Suh,Michael Downes,Ronald M. Evans,Annette Atkins,Senyon Choe,Witek Kwiatkowski
申请号：
US15092481
公开号：
US09925243B2
申请日:
2016.04.06
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present disclosure provides chimeric proteins having an N-terminus coupled to a C-terminus, wherein the N-terminus comprises an N-terminal portion of fibroblast growth factor (FGF) 2 and the C-terminus comprises a portion of an FGF1 protein, wherein the chimeric protein comprises at least 95% sequence identity to SEQ ID NO: 9, 10, 11, 12 or 13. Also provided are nucleic acid molecules that encode such proteins, and vectors and cells that include such nucleic acids. Methods of using the disclosed molecules to reduce blood glucose levels are also provided.
