WILLY PICOUL,ALAIN MOUSSY,CLAIRE SCHALON,ABDELLAH BENJAHAD,DIDIER PEZ,EMMANUEL CHEVENIER,FRANCK SANDRINELLI,JASON MARTIN
申请号：
ARP140102316
公开号：
AR096654A1
申请日:
2014.06.19
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
These compounds modulate, regulate and \/ or inhibit selectively mediated signal transduction, certain native and \/ or Mutant Protein Kinases involved in a variety of Human and animal diseases such as allergic disorders of cellular proliferative, Metabolic, and Degen Erativos.In particular, these compounds are potent and Selective inhibitors of a native and \/ or c-kit Mutant.Claim 1: a compound of formula (1), where a is an aryl group or a heteroaryl Group n is 1, 2, 3, 4 or 5 each r\u00b9 is independently Hydrogen, halogen, a nh\u2082, Oh, CN, an alkyl group or an aryl group or a heteroaryl Group, where the alkyl Group.The Group and the group are insustituidos heteroaryl aryl or substituted by one or more substituents selected from a Halogen, a linear or branched alkyl group c\u2081\u208b\u2086 c\u2081\u208b\u2084, an alkoxy Group, a group haloalquilo c\u2081\u208b\u2084 hidroxialquilo c\u2081\u208b\u2084, a Group, a Group cicloalquil Or c\u2083\u208b\u2087 aryl, heteroaryl Group, a Group, a Group heterocicloalquilo, hydroxyl, a tioalquilo, cyano,A haloalcoxi solubilizer, a Group, a Group - NRR, ID - CO - R, - - - nrso\u2082r conrr, so\u2082nrr, where R and R are each independently selected from Hydrogen, an alkyl group or an aryl group or a heteroaryl Group R\u00b2, r\u00b3 and r\u2074 are selected, each one independently, entr And Hydrogen, halogen, a cyano Group, a Group c\u2083\u208b\u2087 c\u2081\u208b\u2086 alkyl, cycloalkyl, an alkoxy Group c\u2081\u208b\u2084,A haloalquilo Group - a Group c\u2081\u208b\u2084, NRR, ID - CO - conrr R, where R and R are each independently selected from Hydrogen, an alkyl group, or c\u2081\u208b\u2086 r\u2075 is Hydrogen, an alkyl group or a Group c\u2081\u208b\u2086 solubilizer X is - (c = o) -, - O -, - S -, - or - - nr\u2076 (ch\u2082) \u2099 - Gift N is 0, 1 or 2 and r\u2076 represents a hydrogenAn alkyl group or a Group c\u2081\u208b\u2086 solubilizer Q is an alkyl group or an aryl group or a group or a heteroaryl Group
