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INNERVATION OF ENGINEERED STRUCTURES
专利权人:
发明人:
申请号:
EP13743292.8
公开号:
EP2809269A1
申请日:
2013.01.31
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
Methods of generating tubular, bioengineered, smooth muscle structures are disclosed as well as bioengineered tissue for tubular organ repair or replacement. The methods can include the steps of obtaining smooth muscle cells culturing the muscle cells to form a smooth muscle cell construct of directionally oriented smooth muscle cells disposing the smooth muscle cell construct around a tubular scaffold and culturing construct and scaffold in a growth media until a smooth muscle cell structure is achieved. The step of obtain smooth muscle cells can further include obtaining autologous smooth muscle cells from a subject. In one preferred embodiment, the muscle cells can first be on a fibrin substrate to form a muscle construct, which is then disposed around a tubular scaffold, for example, a chitosan scaffold. The methods of the present invention can further include connecting two or more tubular structures together to form an elongate composite structure.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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