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AZACARBOLINE DERIVATIVES,PREPARATION THEREOF,AND THERAPEUTIC USE THEREOF AS KINASE INHIBITORS
专利权人:
SANOFI-AVENTIS
发明人:
ARENDT CHRISTOPHER,BABIN DIDIER,BEDEL OLIVIER,GOUYON THIERRY,LEVIT MIKHAIL,MIGNANI SERGE,MOORCROFT NEIL,PAPIN DAVID,LI RONGHUA
申请号:
ZA201008387
公开号:
ZA201008387B
申请日:
2010.11.23
申请国别(地区):
ZA
年份:
2012
代理人:
摘要:
The invention relates to novel azacarbonlines having formula (I), wherein: R3, R4 represent independently H; hal; CF3; substituted oxy, optionally substituted alkoxy; optionally substituted amino; substituted carbonyl; optionally substituted carboxyl; optionally substituted amide; sulphur, such as optionally substituted sulphones, sulphoxides or sulphides; linear, branched or cyclic C1-C10 alkyl optionally comprising an optionally substituted heteroatom; optionally substituted linear, branched or cyclic C2-C7 alkenyl; optionally substituted linear or branched C2-C6 alkynyl; optionally substituted aryl or heteroaryl; of which may be optionally substituted; in the form of a base or an acid addition salt. The invention also relates to the use of same in therapeutics for the treatment of cancer and to synthesis methods.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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