SQUIERS, Elizabeth C.,ERLICH, Shai,ROTHENSTEIN, Daniel,SHARON, Nir,ODENHEIMER, Daniel J.,FEINSTEIN, Elena
申请号：
LT15729289
公开号：
LT3149172T
申请日:
2015.05.27
申请国别(地区):
LT
年份:
2018
代理人:
摘要：
The invention, in some embodiments, relates to compounds and methods for the prevention of ischemia reperfusion injury (IRI) in organs, and in particular to IRI in organs aged 35 years and older. Specific uses include prevention of IRI in native organs in vivo, in reimplantations and in transplantations of donor organs aged 35 years and older. Additional embodiments include the prophylaxis of delayed graft function (DGF) and reduction in the frequency, amount and duration of dialysis in recipients of deceased donor kidney transplantations. The methods entail contacting the organ in vivo or ex vivo with a temporary p53 inhibitor. Novel temporary dsNA p53 inhibitors are further provided.
