The disclosure includes implementations for providing a personalized medical emergency autopilot system based on data from a portable medical device. A method may include receiving, by a communication unit of a vehicle, a wireless message from a wireless network. The wireless message includes sensor data describing one or more current physiological signals of a driver of the vehicle that are recorded by a portable medical device worn by the driver. The method may include analyzing the one or more current physiological signals of the driver to identify a medical emergency for the driver. The method may include overriding, by a personalized medical emergency autopilot system, one or more vehicle control inputs provided by the driver subsequent to identifying the medical emergency so that the driver cannot control the operation of the vehicle during the medical emergency.