INEB - INSTITUTO NACIONAL DE ENGENHARIA BIOMÉDICA;ISEP - INSTITUTO SUPERIOR DE ENGENHARIA DO PORTO
发明人:
Fernando Jorge MONTEIRO,Susana Maria RIBEIRO E SOUSA MENDES DE FREITAS,Catarina COELHO,Nuno Paulo ALEGRETE DA SILVA
申请号：
US15305435
公开号：
US20170042936A1
申请日:
2015.04.21
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present disclosure relates to a composition for treatment and/or prevention of infections, namely bone diseases, in particular osteomyelitis, via a controlled release of antibiotics and subsequently induce regeneration of bone tissue that often undergoes necrosis due to infection. The present disclosure relates in particular to a pharmaceutical composition comprising one or more granules containing calcium phosphate, collagen and one or more polymers of heparin, and an antibiotic in an effective therapeutic amount, wherein the antibiotic is bound to the heparin polymers.
