WOJTKIELEWICZ, AGNIESZKA,OKLESTKOVA, JANA,MORZYCKI, JACEK WITOLD,HOFFMANNOVA, LUCIE,STRNAD, MIROSLAV
申请号：
NZ59421710
公开号：
NZ594217A
申请日:
2010.02.08
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed are saponin compounds of Formula II, and methods of their preparation. Specific examples of compounds of Formula II include (20S)-21-benzyloxy-20-methylpregn-5-ene-3[beta],16[beta]17[alpha]-triol 16-O-{ 2-O-(4-methoxybenzoyl)-[beta]-D-xylopyranosyl-(13)-2-O-acetyl-[alpha]-L-arabinopyranoside, and (20R)-21-O-pentanoyl-20-methylpregn-5-ene-3[beta],16[beta],17[alpha],21-tetraol 16-O-{ 2-O-(4-methoxybenzoyl)-[beta]-D-xylopyranosyl-(13)-2-O-acetyl-[alpha]-L-arabinopyranoside} . The saponin compounds inhibit cell proliferation and induce cell apoptosis. The compounds are useful for treating proliferative disorders such as cancer, restenosis, rheumatoid arthritis, lupus, type I diabetes, multiple sclerosis, Alzheimer´s disease, growth of parasites, graft rejection, graft versus host disease, polycystic kidney disease, and gout.
