A process for the preparation of liposomes comprising homogenization of a mixture of water and a preformed solution of (i) at least one phospholipid; and (ii) at least one water soluble solvent; wherein at least one phospholipid is phosphatidylcholine and homogenization is performed at about 3000 rpm to about 20000 rpm and the amount of lipid in the water-soluble solvents ranges from 0.001 to 30% wt/wt percentage.