KNOETGEN, HENDRIK,SCHMITTNAEGEL, MARTINA,KLEIN, CHRISTIAN,UMANA, PABLO
申请号：
CA2887486
公开号：
CA2887486A1
申请日:
2013.11.26
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Herein is reported a multi-function protein, characterized in that it comprises exactly one antigen presenting domain, exactly one antibody Fc-region, and at least one antigen binding site, wherein the antigen presenting domain comprises in N- to C-terminal direction either (i) a ß2-microglobulin, and (ii) the extracellular domains a1, a2, and a3 of a class I MHC molecule with a relative frequency of less than 1 %, or (i) a T-cell response eliciting peptide, (ii) a ß2-microglobulin, and (iii) the extracellular domains a1, a2, and a3 of a class I MHC molecule with a relative frequency of 1 % or more, wherein the antigen binding site binds to a cancer cell surface antigen.
