COMPOSITIONS AND METHODS RELATING TO HINDERING DOT1L RECRUITMENT BY MLL-FUSION PROTEINS

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专利权人:

The Regents of The University of Michigan

发明人:

NIKOLOVSKA-COLESKA, Zaneta,SHEN, Chenxi,HESS, Jay

申请号：

EP14751922

公开号：

EP2956470A4

申请日:

2014.02.14

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

The present invention relates to MLL fusion proteins (e.g., AF9 and ENL), which activate target genes in part via recruitment of histone methyltransferase DOT1L. In particular, the present invention provides the AF9/ENL binding site in DOT1L and agents that block the protein-protein interactions between AF9/ENL and DOT1L, therefore inhibiting the activity of DOT1L, and inhibiting MLL-fusion protein associated leukemia.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/