The present disclosure relates approaches for removing or reducing the effectsof motionin parallel and non-parallel data acquisitions using a nuclear medicineimaging system.In certain embodiments, translation vectors (130) are derived based on aregistration(120) performed on transaxial slices (116) generated from the acquiredprojection data(104). The translation vectors (130) may be employed to update (142) a systemmatrix(110) such that images generated using the updated system matrix (144) arefree ormotion artifacts or have reduced motion artifacts.