Derek Jantz,James Jefferson Smith,Michael G. Nicholson,Daniel T. MacLeod,Jeyaraj Antony,Victor Bartsevich
申请号：
US15864984
公开号：
US09950010B1
申请日:
2018.01.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed herein is a genetically-modified cell comprising in its genome a modified human T cell receptor alpha constant region gene, wherein the cell has reduced cell-surface expression of the endogenous T cell receptor. The present disclosure further relates to methods for producing such a genetically-modified cell, and to methods of using such a cell for treating a disease in a subject.
