BEHENNA, DOUGLAS CARL,CHENG, HENGMIAO,CHO-SCHULTZ, SUJIN,PLANKEN, SIMON PAUL,KATH, JOHN CHARLES,NAGATA, ASAKO,NAIR, SAJIV KRISHNAN,JOHNSON JR., THEODORE OTTO
申请号：
PE0006502016
公开号：
PE08852016A1
申请日:
2014.11.10
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
Refers to purine Derivatives of formula (i), or pharmaceutically acceptable salts of the same, in which c1\u2013c6 R1 is H, alkyl, cycloalkyl alquenilo c2\u2013c6, c3\u2013c6 heteroaryl, 4 to 6 members, among others The Ring a is aryl or heteroaryl c6\u2013c10 5 to 12 members R2 and R5 in Dependently are absent or are h, halogen, CN, CF3, c1\u2013c6 CHF2, alkyl, cycloalkyl c3\u2013c6,Among others R3 is absent or c1\u2013c6 h, halogen, alkoxy alkyl, cycloalkyl c3\u2013c6 c1\u2013c6, among others R4 is absent or is H, halogen, alkyl or cycloalkyl c1\u2013c6 c3\u2013c6 Q is absent or is o, s or NH, among others The Ring B is absent or c3\u2013c10 cycloalkyl, aryl c6\u2013c1 Heteroaryl 0 or 5 to 12 members, among others and R8 R6 independently are absent or are h, halogen, NS,Oh, c1\u2013c3 c1\u2013c3 alkyl, alkoxy, among others R7 is \u2013g\u2013c (OR) \u2013ch = CH2 = CH2, \u2013g\u2013so2\u2013ch, \u2013g\u2013c \u2013ch2cl \u2013g\u2013c (OR), (OR) \u2013ch2\u2013cn, among others g is absent when the point of attachment to a B Atom is n, or when the junction is NR18 B is a c Atom, where R18 is H or alkyl Or c1\u2013c3 and M is 0, 1 or 2, with the condition that m is 2 when the Ring B is absent.It also relates to pharmaceutical compositions containing Said Derivatives of purine. Purine Derivatives of formula (i) are useful for treating abnormal cell growth in Mammals, such as cancer.Se refiere a derivados de purina de formula (I) o sales farmaceuticamente aceptables de los mismos, en los cuales R1 es H, alquilo C1–C6, alquenilo C2–C6, cicloalquilo C3–C6, heteroarilo de 4 a 6 miembros, entre otros el anillo A es arilo C6–C10 o heteroarilo de 5 a 12 miembros R2 y R5 independientemente estan ausentes o son H, halogeno, CN, CHF2, CF3, alquilo C1–C6, cicloalquilo C3–C6, entre otros R3 esta ausente o es H, halogeno, alquilo C1–C6, alcoxi C1–C6, cicloalquilo C3–C6, entre otros R4 esta ausente o es H, halogeno, alquilo C1–C6 o cicloalquilo C3–C6 Q esta ausente o es O, S o N
