THE CHILDREN'S HOSPITAL OF PHILADELPHIA;THE CHILDRENS HOSPITAL OF PHILADELPHIA
发明人:
STACHELEK, STANLEY J.,FINLEY, MATTHEW J.,LEVY, ROBERT J.
申请号：
CA2867864
公开号：
CA2867864A1
申请日:
2013.03.15
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Methods for inhibiting a biomaterial-associated thrombotic event comprise reducing the number of platelets that bind to the biomaterial, or inhibiting platelet activation, by attaching CD47 or the Ig domain thereof to the surface of the biomaterial. Methods of the present invention inhibit thrombi formation on or near a biomaterial that is on the surface of an implant, medical device, tube, or therapeutic delivery vehicle. Also provided are kits for practicing these methods and the modified biomaterials.
