Joshua E. ALLEN,Martin STOGNIEW,Varun Vijay PRABHU
申请号：
US16526444
公开号：
US20200022982A1
申请日:
2019.07.30
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Imipridones selectively modulate Class A G protein-coupled receptors (GPCRs), such as the D2-like subfamily of dopamine receptors, and are useful for treating conditions and disorders in need of such modulation, such as cancers. Specifically, the cancer is a midline glioma, a cancer having a histone H3 mutation, or both. In addition, methods of identifying whether a subject having these conditions, is likely to be responsive to a treatment regimen, such as imipridone administration, are provided. Furthermore, methods of assessing the effectiveness of a treatment regimen, such as imipridone administration, monitoring, or providing a prognosis for a subject with these condition are also provided.
