Michael G. Rosenblum,Khalid Amanali Mohamedali,Lawrence H. Cheung
申请号：
US14322083
公开号：
US09499807B2
申请日:
2014.07.02
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.
