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IMPROVED FORMULATIONS OF LEVOSIMENDAN FOR INTRAVENOUS ADMINISTRATION AS INFUSION OR INJECTION AND OF INFUSION CONCENTRATE
专利权人:
发明人:
WEILAND ANDREA
申请号:
IN201817013373
公开号:
IN201817013373A
申请日:
2018.04.07
申请国别(地区):
IN
年份:
2018
代理人:
摘要:
The present invention relates to improved formulations of Levosimendan for pharmaceutical use and particularly for intravenous administration as infusion or injection and of infusion concentrates. The present invention therefore relates to pharmaceutical compositions comprising Levosimendan in which Levosimendan ispresent in a solubilized form. The formulations have therapeuticallyand commercial useful concentrations of Levosimendan. The solutions of the invention have enhanced ability at physiological pH (pH 7.4) and are particular useful as infusion or injection solutions or infusion concentrates. The composition according to the present invention can also be spray dried or lyophilized to obtain a dried powder which is very stable and which powder forms the original solutionafter reconstitution in wateror an aqueous solvent. Levosimendan or ( ) 4 (1 4 5 6 tetrahydro 4 methyl 6 oxo 3 pyridazi nyl)phenyl hydrazono propanedinitrile is useful in the treatment of congestive heart failure.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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