It provides one kind and is used to prepare the particle that orally disintegrating tablet (ODT) composition includes the masked active medicine mixture of one or more tastes, rapidly-disperse particles agent method, other are selectable, pharmaceutically acceptable excipients, wherein with formed one it is smooth, the saliva contacts in oral cavity readily hung to swallow, ODT are decomposed. Furthermore, it is quick when being placed in oral cavity and providing, the dosage on the entrance of stomach substantially-thoroughly loosen when, particle (including active crystal, particle, pearl or particle), coated with a taste-masking film include a polymer not soluble in water and one or more gastrosoluble is inorganic or organic hole is pervious (dissolves in actually insoluble in water and the saliva of an acidic buffer, but), show acceptable taste-masking.