Nanofiber having self-heating property and bioactive substance release property, method for producing the same, self-heating property and bioactive substance release functional nonwoven fabric
The present invention relates to a nanofiber having a self-heating property and a bioactive substance-releasing property that can self-heat and simultaneously release a drug, and can be safely used in the human body without diffusing the self-heating nanoparticles, a method for producing the nanofiber It is an object of the present invention to provide a functional and physiologically active substance releasing functional nonwoven fabric. A fiber having a diameter of 50 nm to 50 μm and a length of 100 times or more of the diameter, and self-heating particles that generate heat in response to an external stimulus, and a physical property that reacts directly or indirectly to the stimulus A fiber in which the physiologically active substance is released to the outside in response to a change in physical properties of the stimulus-responsive polymer. , Its production method and self-heating and bioactive substance release functional nonwoven fabric.本発明は、自己発熱させると同時に薬物放出可能で、自己発熱ナノ粒子を拡散させることなく、人体に安全に利用できる自己発熱性及び生理活性物質放出性を有するナノファイバー、その製造方法及び自己発熱性及び生理活性物質放出機能性不織布を提供することを課題とする。直径が５０ｎｍ～５０μｍ、長さが前記直径の１００倍以上のファイバーであって、外部からの刺激に応じて発熱する自己発熱粒子と、前記刺激に直接的又は間接的に反応して物理的性質が変化する刺激応答性ポリマーと、前記刺激応答性ポリマーに保持される生理活性物質とを含み、前記刺激応答性ポリマーの物理的性質の変化に応じて前記生理活性物質が外部に放出されるファイバー、その製造方法及び自己発熱性及び生理活性物質放出機能性不織布である。
