JUNG, Woo Chang,정우창,LEE, Sang Jun,이상준,JUNG, Se Young,정세영
申请号：
KRKR2019/008925
公开号：
WO2020/040432A1
申请日:
2019.07.19
申请国别(地区):
KR
年份:
2020
代理人:
摘要：
The present invention relates to a pharmaceutical composition for preventing or treating muscle diseases, the composition containing a ginseng berry (Panax ginseng berry) extract as an active ingredient. The composition, according to the present invention, may be usefully employed for preventing, improving or treating muscle diseases by mitigating the reduction of muscle mass and the muscle fiber cross-sectional area caused by muscle atrophy, and by mitigating an increase in the expressions of muscle RING-finger protein-1 (MuRF-1) and atrogin-1 which are involved in muscle proteolysis.La présente invention concerne une composition pharmaceutique pour prévenir ou traiter des maladies musculaires, la composition contenant un extrait de baie de ginseng (baie de Panax ginseng) en tant que principe actif. La composition, selon la présente invention, peut être utilisée utilement pour prévenir, améliorer ou traiter des maladies musculaires en atténuant la perte de la masse musculaire et de l'épaisseur transversale de la fibre musculaire provoquées par l'atrophie musculaire, et en atténuant l'augmentation de l'expression des gènes des protéines musculaires MuRF-1 (pour "RING-finger protein-1") et atrogine-1 qui sont impliquées dans la protéolyse musculaire.본 발명은 인삼열매(Panax ginseng berry) 추출물을 유효성분으로 포함하는 근육 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명의 조성물은 근위축에 따른 근육 무게 및 근섬유 단면적의 감소를 완화시키고, 근육 단백질의 분해에 관여하는 MuRF-1(Muscle RING-finger protein-1) 및 아트로진-1(atrogin-1)의 발현 증가를 완화시킴으로써, 근육 질환을 예방, 개선 또는 치료하는 데 유용하게 이용될 수 있다.
