KIM, TAE KYUNG,金泰卿,AHN, YOUNG_JOO,安永珠,WOO, JUNG WON,禹晶媛,KANG, MI SOO,姜美收,YANG, SANG-IN,杨尚仁,楊尚仁,SEO, JI-YOUNG,徐智英,PARK, HYUN HEE,朴贤熙,朴賢熙,CHA, JI-EUN,车志恩,車志恩,BYUN, MI SUN,卞美仙,LEE
申请号：
TW106105296
公开号：
TW201729831A
申请日:
2017.02.17
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
The present disclosμre relates to a pharmaceμtical composition for treating growth hormone deficiency, containing hGH-hyFc (GX-H9) which is a recombinant hμman growth hormone prepared by fμsing hybrid Fc to hμman growth hormone hGH. More particμlarly, the present disclosμre relates to a appropriate method of administering a recombinant hGH which is effective to treat the growth hormone deficiency and to a pharmaceμtical composition for treating growth hormone deficiency, inclμding a recombinant hGH GX-H9 and a pharmaceμtically acceptable carrier, in which the recombinant hGH GX-H9 is administered once a week with a dosage of 0.1 to 0.3 mg per weight kg of a patient or twice-monthly with a dosage of 0.1 to 0.4 mg per weight kg of the patient. Fμrther, the present disclosμre relates to a method for treating growth hormone deficiency, inclμding administering an recombinant hGH GX-H9 to a patient with growth hormone deficiency once a week with a dosage of 0.1 to 0.3 mg per weight kg of the patient or twice-monthly with a dosage of 0.1 to 0.4 mg per weight kg of the patient.本發明揭露包含用於治療生長激素缺乏症的重組人類生長激素hμman growth hormone(HGH,hGH)的藥物組合物，包括hGH-hyFc（GX-H9），通過雜合Fc與hGH融合而製備的重組hGH。更具體地，本發明揭露於製備治療生長激素缺乏症之重組hGH藥物的用途和有效用於治療生長激素缺乏症的藥物組合物，包括重組hGH GX-H9和藥學上可接受的載體，其中劑量為0.1至0.3mg / kg 體重(病患體重)，hGH GX-H9每週給藥一次，或劑量為0.1至0.4mg / kg 體重，hGH GX-H9每月給藥兩次。本發明揭露製備治療生長激素缺乏症之重組hGH藥物的用途，向生長激素缺乏症的患者給藥重組hGH GX-H9，劑量為0.1-0.3mg / kg 體重，每週一次；劑量為0.1至0.4mg / kg 體重每月兩次。
