BIPARATOPIC POLYPEPTIDES ANTAGONIZING WNT SIGNALING IN TUMOR CELLS

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专利权人:

BOEHRINGER INGELHEIM INTERNATIONAL GMBH

发明人:

ZINZALLA, Vittoria,KUENKELE, Klaus-Peter,BUYSE, Marie-Ange,CROMIE, Karen,STAELENS, Stephanie,STRUBBE, Beatrijs

申请号：

SG11201804510P

公开号：

SG11201804510PA

申请日:

2016.12.02

申请国别(地区):

SG

年份:

2018

代理人:

摘要：

The invention provides novel biparatopic LRP5/LRP6 cross-reactive binding polypeptides, and more specifically novel biparatopic LRP5/LRP6 cross-reactive immunoglobulin single variable domain constructs which can inhibit Wnt signaling pathways. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as cancer.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/