STABILIZED POLYMERIC THIOL REAGENTS

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专利权人:

发明人:

申请号：

EP05855832.1

公开号：

EP1827501B2

申请日:

2005.12.21

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

Disclosed are water soluble polymeric reagents comprising the structure POLY-[Y&mdashS&mdashW]x, where POLY is a water soluble polymer Y is a hydrocarbon-based spacer group, x is 1 to 25, and S&mdashW is a thiol, protected thiol, or thiol-reactive derivative. Preferably, the water soluble polymer is a PEG polymer. Also disclosed are conjugates of such polymeric reagents with pharmaceutically relevant molecules, and methods of their formation and use.

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