The present invention relates to a cosmetic composition with anti-inflammation and skin regeneration effects including barley extracts as an active ingredient, and more specifically, to a cosmetic composition which uses nucleic acid to improve anti-inflammation and skin regeneration effects. The present invention includes 0.01-10 wt% of barley extracts relative to the 100 wt% of cosmetic composition. [Reference numerals] (AA) Control group; (BB) Process group of a comparative example 1; (CC) Process group of an example 1본 발명은 발아 보리추출물을 유효성분으로 함유하는 항염 및 피부 재생 효능을 갖는 화장료 조성물로서, 항염 및 피부 재생 효능 성분의 효과를 배가시키기 위하여 연어 정소에서 추출한 핵산을 혼합 사용하는, 화장료 조성물에 관한 것이다.