ALFREDO C. CASTRO,KRISTOPHER M. DEPEW,MICHAEL J. GROGAN,EDWARD B. HOLSON,BRIAN T. HOPKINS,CHARLES W. JOHANNES,GREGG F. KEANEY,NII O. KONEY,TAO LIU,DAVID A. MANN,MARTA NEVALAINEN,STEPHANE PELUSO,LAWREN
申请号：
BRPI0715745
公开号：
BRPI0715745A2
申请日:
2007.08.21
申请国别(地区):
BR
年份:
2013
代理人:
摘要：
COMPOUNDS AND METHODS TO INHIBIT INTERACTION OF BCL PROTEINS WITH LINKING PARTNERS. The present invention relates to isoxazolidine-containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used to treat and modulate disorders associated with hyperproliferation, such as cancer.COMPOSTOS E MÉTODOS PARA INIBIR A INTERAÇçO DE PROTEÍNAS BCL COM PARCEIROS LIGANTES. A presente invenção refere-se a compostos contendo isoxazolidina que se ligam a proteínas bcl e inibem a função de Bcl. Os compostos podem ser usados para tratar e modular distúrbios associados à hiperproliferação, tal como câncer.
