您的位置: 首页 > 农业专利 > 详情页

THERAPEUTIC APPLICATIONS
专利权人:
ГЛЭКСОСМИТКЛАЙН ИНТЕЛЛЕКЧУАЛ ПРОПЕРТИ ДИВЕЛОПМЕНТ ЛИМИТЕД (GB)
发明人:
ВАН Жун (CN),ЛУ Хунтао (CN)
申请号:
RU2014133544
公开号:
RU2014133544A
申请日:
2013.01.15
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A compound that is an inverse agonist of H3 receptors for use in slowing, stopping, or reversing the development of disability in multiple sclerosis (MS). 2. The compound of claim 1, wherein the compound is 1- {6 - [(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl) oxy] -3-pyridinyl} - 2-pyrrolidinone, 3- (benzo [d] [1,3] dioxol-5-yl) -5 - ((1-cyclobutylpiperidin-4-yl) methyl) -1,2,4-oxadiazole or 4- (4 - ((1-Isopropylpiperidin-4-yl) oxy) piperidin-1-yl) benzonitrile; or their pharmaceutically acceptable salts. 3. The compound of claim 2, wherein the compound is 1- {6 - [(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl) oxy] -3-pyridinyl} - 2-pyrrolidinone or a pharmaceutically acceptable salt thereof. 4. The compound according to any one of paragraphs. 1-3, in which the compound is administered orally to a person at a dose of 5-500 micrograms per day. The compound according to any one of paragraphs. 1-3, in which the compound is administered orally to a person at a dose of 10-150 micrograms per day. A compound that is an inverse agonist of H3 receptors for use in the treatment of demyelinating diseases, wherein the compound is 1- {6 - [(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7 -yl) hydroxy] -3-pyridinyl} -2-pyrrolidinone, 3- (benzo [d] [1,3] dioxol-5-yl) -5 - ((1-cyclobutylpiperidin-4-yl) methyl) -1 , 2,4-oxadiazole or 4- (4 - ((1-isopropylpiperidin-4-yl) oxy) piperidin-1-yl) benzonitrile; or their pharmaceutically acceptable salts. 7. The compound of claim 6, wherein the compound is 1- {6 - [(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl) oxy] -3-pyridinyl} - 2-pyrrolidinone or a pharmaceutically acceptable salt thereof. 8. A compound that is an inverse agonist of H3 receptors for use in stimulating demyelination, wherein the compound is 1- {6 - [(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7- il) oxy] -3-pyridinyl} -2-pyrrolidi1. Соединение, которое представляет собой обратный агонист H3-рецепторов, для применения в замедлении,
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关专利

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充