The invention provides a composition including at least one iron chelating compound for use in a method of treating or preventing a fungal condition. The composition can include the iron chelating compounds deferiprone or deferasirox. An antifungal agent included in the composition can include a polyene antifungal agent, an azole antifungal agent or an echinocandin antifungal agent. The method includes administering to an individual having, or susceptible to having, a fungal condition a therapeutically effective amount of at least one iron chelating compound for a sufficient time to reduce the severity of a fungal condition, wherein the iron chelating compound comprises a non-siderophore or non-xenosiderophore relative to the fungal condition. Provided further by the invention is the prophylactic administration of the at least one iron chelating compound or at least one iron chelating compound prior to onset of the fungal condition.
