ВАСКОНСЕЛОС Теофило Кардосо Де (PT),ЛИМА Рикардо Хорге ДОС Сантос (PT),БАРРОКАС Педро Мигель да Коста (PT),ПЕРЕЙРА Лигия София де Кастро (PT),КОСТА Руи Сердеира де Кампос (PT)
申请号：
RU2011143619/15
公开号：
RU2011143619A
申请日:
2010.03.31
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A stable composition comprising: at least one active pharmaceutical ingredient (API) selected from 2,5-dichloro-3- (5- (3,4-dihydroxy-5-nitrophenyl) -1,2,4- oxadiazol-3-yl) -4,6-dimethylpyridin 1-oxide and 5- [3- (2,5-dichloro-4,6-dimethylpyridin-3-yl) - [1,2,4] oxadiazol-5- silt] -3-nitrobenzene-1,2-diol and their salts, esters, hydrates, solvates and other derivatives； at least one filler； and at least one binder component； where at least one active pharmaceutical ingredient (API) is present in granular form. The stable composition according to claim 1, where at least one API is a combination of 2,5-dichloro-3- (5- (3,4-dihydroxy-5-nitrophenyl) -1,2,4-oxadiazole-3- il) -4,6-dimethylpyridine 1-oxide and 5- [3- (2,5-dichloro-4,6-dimethylpyridin-3-yl) - [1,2,4] oxadiazol-5-yl] -3 nitrobenzene-1,2-diol. 3. The stable composition according to claim 2, where less than 10% of the API decomposes in more than 15 days of storage at a temperature of 70 ° C and uncontrolled humidity, more than 6 months of storage at a temperature of 40 ° C and a relative humidity of 75%, and / or more than 3 years of storage at a relative humidity of 60% and a temperature of 30 ° C or 25 ° C. 4. The stable composition according to claim 3, wherein less than 5% of the API decomposes in more than 15 days of storage at a temperature of 70 ° C and uncontrolled humidity, more than 6 months of storage at a temperature of 40 ° C and a relative humidity of 75%, and / or more than 3 years of storage at a relative humidity of 60% and a temperature of 30 ° C or 25 ° C. 5. The stable composition according to claim 4, where less than 3% of the API decomposes in more than 15 days of storage at a temperature of 70 ° C and uncontrolled humidity, more than 6 months of storage at a temperature of 40 ° C and a relative humidity of 75%, and / or more than over 3 years of storage1. Устойчивая композиция, включающая:по крайней мере, один активный фармацевтический ингредиент (АФИ), выбранный из 2,5-дихлор-3-(5-(
